Innovative approach to human longevity
As we all know, the simplicity is the ultimate sophistication. Contemporary medicine understands simplicity as the perfection of the idea, beauty of the concept, out-of-the-box realization and science-driven solution. Besides, to achieve the great scientific goal we need understanding of the fundamental aspects of the issue, adequate scope of the novel evidence, team of experts, appropriate equipment and a new hypothesis, which is not always simple. However, all prerequisites are available in the biotechnologies that have been developed by the NeuroVita Clinic.
Simplicity and ingenuity of the scientific idea of the Russian scientists lies in the fundamental research of one type of the cells, the hematopoietic stem cell of a human body that appears to contain the solution to the detection and treatment of the diseases of the civilization that accumulate in the body with the time due unfavorable environment long before manifestation of the clinical symptoms. The team of Prof. Bryukhovetskiy shows that the post-genomic (proteomic and transcriptomic) molecular-biological and cytofluorimetric analysis of the protein antigens of the membrane surface of the human HSCs permit detection of the fatal disease long before its clinical symptoms. Unique but simple manipulations with the HSC and the chemical induction of the HSCs and their microenvironment permit obtaining the repaired, that is, healthy HSCs from autologous healthy somatic cells of the skin, fat, and/or muscles. The transfusion of the repaired HSCs promotes replacement of the damaged cells of the immune system with the healthy cells and permits avoiding of the most of fatal disease of civilization and/or prevent their relapses.
In the context of the proposed theory, Prof. Bryukhovetskiy and the team show that ageing of humans is conditioned by the disorders or damages of the molecular-biologic mechanisms of the systemic immune control and surveillance of the immune system and not by the exhaustion and age of the specialized cells of the tissues and organs. The disease-specific post-genome changes of the HSCs and the disorders of their regulatory function induce either the phenomenon of the hyporeactivity when the immune system does not detect the pathological cells as in cancer, or the phenomenon of the hyperreactivity when the immune system overreacts and destroys the specialized cells of the bodies and tissues as in the autoimmune and neurodegenerative diseases. These phenomena manifest in the changes of the proteomic structure of the HSCs and disease-specific proteins in it at the molecular-biological level leading to the loss of control over the injured cells and onset of the disease-specific immune insufficiency. The scientific discovery shows that immune insufficiency is different from the primary or secondary as it happens in the case of the AIDS or other infectious diseases, and, namely, qualitative genomic-protein and RNA degeneration of the immune-competent cells (ICCs) and HSCs while the quantity of the cells and their normal balance in the peripheral blood remain the same. This phenomenon is caused by the genomic and post-genomic (proteomic) damage of the HSC, the slowest cell of a human body, induced by unfavorable environment like ionizing radiation, UHF, injuries, infections, intoxications or endogenous factors or endogenous factors like the carcinogens, local or systemic inflammation, ischemia and other. The genomic and postgenomic injury of the HSC at the level of the proteome, transcriptome, secretome and metabolome, in the bone marrow niches induces irreversible disorders of the protein structures of all progeny of the ICC of the blood, such as aseptic inflammation in the specialized cells, change of their phenotype and irreversible changes in the specialized tissues like degeneration and atrophy of the specialized cells or, on the contrary, their uncontrolled growth. The cell cycle of the HSCs is 360 days, while all cells of the immune and hematopoietic systems are the progeny of the HSCs and live for 120 days. The post-genomic changes of the proteomic structure of the HSCs lead to long term inefficiency of the function of all progeny of the ICC in blood in a new generation.
The scientists of NeuroVita Clinic show that if the human body restores normal quantitative balance of the HSCs replacing them with closely related precursors of the hematopoiesis or restoring their proteomic structure, it helps recover genetic and post-genomic mechanisms of the self-restoration of the human similar to that at a young age. It extends the active phase and life period at least by 30 to 40 years and even leads to the restoration of the reproductive function. Healthy HSCs are able to restore esthetic condition of the skin and somatic well-being of the organs and tissues, to normalize the internal state of the tissues and cell-tissular structure of the organs damaged by the environment.
The theory of Prof. Bryukhovetskiy provides an academic explanation for the longevity mentioned in the Bible. It says that the patriarchs lived for about 1000 years. The mathematical models of the neurons provided by our mathematicians proved the biologic consistency of these data and showed that the neural cells of the humans are able to survive for over 1000 years and normal functioning of the HSC can provide for the regeneration of the organs and tissues.
In other words, ageing of the humans and almost all age-related diseases conditioned by the unfavorable environment are the variety of the proteomic disease of the main bioregulator of the human’s body, i.e. person’s own HSCs. The post-genomic (proteomic) damage of the HSC that was caused by the internal and external factors of the environment is the fundamental scientific reason of ageing and incurable age-related diseases. In other words, the person dies from the disorder and damage of his basic regulatory systems of the restoration and reproduction of the damaged cells and loss of control after intratissular processes of self-restoration and hematopoiesis. The proteomic damage of the HSC by the negative environment and endogenous factors of homeostasis disorder is a universal tool of the evolution and natural selection given to the human by the creator (God, Nature, Evolution).
In our clinic we isolate your cells and check them for the signs of mortal diseases. Your own healthy stem cells can extend your life by 30 to 40 years and save you from the onset and relapse of the fatal diseases of civilization!